Dietary restriction and fasting downregulate complement activity

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Dietary restriction and fasting downregulate complement activity

Background Seventy-two hours of preoperative fasting (F) or 2 weeks of 30% dietary restriction (DR) offers robust protection against renal ischemia-reperfusion injury (IRI) in mice. However, the mechanism remains to be elucidated. We hypothesize that immunomodulation plays a pivotal role. Innate immunity, especially the complement system, is crucial in the pathophysiology of IRI. Therefore, we ...

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ژورنال

عنوان ژورنال: BMC Proceedings

سال: 2012

ISSN: 1753-6561

DOI: 10.1186/1753-6561-6-s3-p66